Urinary Protein Profile Changes in Diabetic Rats and Pre-diabetic Rats Fed with High Fat Diets
This study aimed to analyze the changes in urinary protein profile in diabetic rats and pre-diabetic rats by the effect of HFD. Urine from ten groups of rats fed with different diet and metformin treatment was resolved by performing 1D electrophoresis. Results show that pre-diabetic rats with normal diet and metformin treatment are more like those of healthy rats with normal diet. This indicates that early metformin treatment, as well as diet control, is effective ways to delay the progression of pre-diabetes to diabetes.